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KMID : 0357920040380020121
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Korean Journal of Pathology
2004 Volume.38 No. 2 p.121 ~ p.125
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Minimal Deviation Adenocarcinoma, Mucinous Type, of the Uterine Cervix- Report of a Case with Extensive Metastasis to the Uterine Corpus and Bilateral Adnexae -
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Chang Eun-Deok
Lee Eun-Jung
Kim Kyoung-Mee
Shin Ok-Ran
Ku Young-Mi
Ahn Hee-Jung
Kang Chang-Suk
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Abstract
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Minimal deviation adenocarcinoma is an extremely well differentiated variant of cervical adenocarcinoma, and is frequently misdiagnosed due to its benign-looking histopathological features. A 38-year-old woman was diagnosed as having had a minimal deviation adenocarcinoma in the cervix, metastasizing to the uterine body and bilateral adnexae. She had a history of right salpingo-oophorectomy 3 years ago, and was diagnosed as having a mucinous cystadenoma. Histologically, the tumor cells were so well-differentiated that they appeared to be almost the same as those of the non-neoplastic cervical glands. Similar glands were found in both ovaries and in the left fallopian tube. PAS staining showed a negative or apical positive pattern in the endocervical-like glands. Immunohistochemical studies for CEA, ER/PR, cytokeratin 20, and p53 were negative, but positive for cytokeratin 7. The HPV DNA microarray test was negative. Clinically, this proved to be an advanced, biologically aggressive disease.
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KEYWORD
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Adenocarcinoma, Mucinous, Cervix
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